Molecular Docking of Mangrove Plant as Therapeutic Agent to Treat Non-Small Cell Lung Carcinoma

Background: Cancer is one of the biggest health problems worldwide, with lung cancer as first rank in number new cases and deaths. Non-small cell carcinoma (NSCLC) a type that accounts for about 85% all cases. Previous research identified role epidermal growth factor receptor (EGFR) most suitable target to treat NSCLC. This study aims identify potential compounds derived from mangrove plants agents NSCLC using molecular docking study. 
 Methodology: Six natural compounds, which include taraxasterol, stigmasterol, tretinoin, heritonin, ascochitine, tricin, along gefitinib drug comparative were used. Docking was carried out on EGFR by Autodock Tools. The visualizations interactions BIOVIA Discovery Studio 2020. Results: results showed six compiled several criteria drugs based Lipinski analysis had an affinity receptors. found order stigmasterol (-11.84 kcal/mol), taraxasterol (10.80 tretinoin (-10.60 tricin (-9.24 ascochitine (-7.85 heritonin (-7.81 (-8.62 kcal/mol). Among these exhibited highest binding affinity. ADME profile are safe drug-like compounds. Conclusion: Stigmasterol energy -11.84 kcal/mol. All three bind pocket EGFR. have drug-likeness properties rules.